1360144-82-6

Basic information

• Product Name: (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl 4-methoxybenzoate
• Synonyms: (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl 4-methoxybenzoate
• CAS NO: 1360144-82-6
• Molecular Weight: 276.246
• Mol File: 1360144-82-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl 4-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl 4-methoxybenzoate(1360144-82-6)
• EPA Substance Registry System: (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl 4-methoxybenzoate(1360144-82-6)

Safety Data

• Hazardous Substances Data: 1360144-82-6(Hazardous Substances Data)

Upstream product

• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 
• 7559-81-1 chlorokojic acid 
• 52509-81-6 potassium 4-methoxybenzoate 
• 15771-06-9 5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one 

Relevant articles and documents

Tyrosinase inhibitor and application thereof

The invention provides a hydroxy-oxo-pyran-methyl ester compound and pharmaceutically-acceptable salts thereof. The hydroxy-oxo-pyran-methyl ester compound has a following structural formula as shownin the description, wherein the hydroxy-oxo-pyran-methyl ester compound is produced by using resveratrol and kojic acid as raw materials, has good tyrosinase inhibitor performance, is safe and effective, and can be widely applied for producing medicines, make-up or fruit and vegetable fresh-keeping agents.

Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities

We synthesized benzoate ester derivatives of kojic acid with and without adamantane moiety. Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities. However, depigmenting activity was not noted in a cell-based assay. Contrasting results were obtained for benzoate derivatives (3a-e) containing an adamantane moiety. Compounds 3a-e showed potent depigmenting activities without tyrosinase inhibitory activities. To the best of our knowledge, this is the first study showing the depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.