136024-63-0

Basic information

• Product Name: (2S,4R)-4-Benzyloxy-2-diethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (2S,4R)-4-Benzyloxy-2-diethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 136024-63-0
• Molecular Weight: 379.497
• Mol File: 136024-63-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-4-Benzyloxy-2-diethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-Benzyloxy-2-diethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(136024-63-0)
• EPA Substance Registry System: (2S,4R)-4-Benzyloxy-2-diethoxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(136024-63-0)

Safety Data

• Hazardous Substances Data: 136024-63-0(Hazardous Substances Data)

Upstream product

• 136024-61-8 (4R)-benzyloxy-(2S)-formylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 122-51-0 orthoformic acid triethyl ester 
• 136024-60-7 1-(tert-butyl) 2-methyl (2S,4R)-4-(benzyloxy)pyrrolidine-1,2-dicarboxylate 
• 109953-95-9 tert-butyl (2S,4R)-4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 100-39-0 benzyl bromide 

Downstream Products

• 136024-66-3 (2-Amino-3-hydroxy-phenyl)-((2S,4R)-4-benzyloxy-2-diethoxymethyl-pyrrolidin-1-yl)-methanone 
• 136024-68-5 2-β-benzyloxytilivalline 

Relevant articles and documents

New methods and reagents in organic synthesis. 92. A stereoselective synthesis of tilivalline and its analogs

Tilivalline (1a), a metabolite from Klebsiella pneumoniae var. oxytoca, and its derivatives 1 have been efficiently and stereoselectively synthesized from diphenyl phosphorazidate, the 2-oxazoline 2, the L-proline derivatives 5, and indole; the key step is a Mannich type intramolecular cyclization accompanied with completely stereoselective introduction of indole. Furthermore, 11-substituted 5H- pyrrolo[2,1-c][1,4]benzodiazepin-5-ones (16) have been also synthesized from the acetal amide 9a and various nucleophiles by the use of this new Mannich type cyclization.