1360538-03-9Relevant articles and documents
Enantioselective synthesis of the carbocyclic nucleoside (-)-abacavir
Boyle, Grant A.,Edlin, Christopher D.,Li, Yongfeng,Liotta, Dennis C.,Morgans, Garreth L.,Musonda, Chitalu C.
, p. 1870 - 1876 (2012/05/04)
An enantiopure β-lactam with a suitably disposed electron withdrawing group on nitrogen, participated in a π-allylpalladium mediated reaction with 2,6-dichloropurine tetrabutylammonium salt to afford an advanced cis-1,4-substituted cyclopentenoid with both high regio- and stereoselectivity. This advanced intermediate was successfully manipulated to the total synthesis of (-)-Abacavir.