1360790-08-4Relevant articles and documents
PLINABULIN PRODRUG ANALOGS AND THERAPEUTIC USES THEREOF
-
Page/Page column 43, (2012/04/04)
Compounds of Formula (I) and (I') are disclosed, as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.
Water-soluble prodrug of antimicrotubule agent plinabulin: Effective strategy with click chemistry
Yakushiji, Fumika,Tanaka, Hironari,Muguruma, Kyohei,Iwahashi, Takahiro,Yamazaki, Yuri,Hayashi, Yoshio
, p. 12587 - 12590 (2011/12/21)
Click for improved solubility: A water-soluble prodrug of plinabulin was designed and synthesized efficiently by using click chemistry in three steps (see scheme). The product was highly water-soluble, and the parent compound could be regenerated by ester