13608-28-1Relevant articles and documents
CONDENSATION REACTION BY METAL CATALYST
-
Page/Page column 24-25, (2008/12/07)
The invention relates to a method for producing an azoline compound represented by the general formula (3): wherein R1 represents an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; R3, R4, R5 and R6 may be the same or different and each represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; two arbitrary groups selected from R3, R4, R5 and R6 may bond to each other to form a ring; and Z1 represents an oxygen atom, a sulfur atom or a selenium atom; comprising reacting a carboxylic acid or a carboxylic acid derivative represented by the general formula (1): ????????R1CO2R2?????(1) wherein R1 is as defined above; R2 represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group; and R1 and R2 may bond to each other to form a ring; with an aminochalcogenide represented by the general formula (2): wherein R3, R4, R5, R6 and Z1 are as defined above; in the presence of a compound containing a group 12 metal element in the periodic table.
Stereoselective Construction of Acyclic Carbon Chains by a One-Pot Coupling Process Based on Alkenyloxazoline-Titanium Complexes
Mitsui, Kazuhisa,Sato, Takayuki,Urabe, Hirokazu,Sato, Fumie
, p. 490 - 492 (2007/10/03)
A versatile organometallic intermediate, an alkenyloxazoline-titanium complex, has been developed that enables one-pot multicomponent diastereoselective and asymmetric coupling processes to be achieved in a remarkably efficient manner (see scheme).
Novel Synthesis of α-Substituted Acrylic Acids
Serota, S.,Simon, J. R.,Murray, E. B.,Linfield, W. M.
, p. 4147 - 4151 (2007/10/02)
A facile three-step procedure has been developed for the synthesis of α-substituted acrylic acids.In the first step, a carboxylic acid having no α-substituents is condensed with 2-amino-2-methylpropanol (AMP) to form the corresponding oxazoline.The oxazoline reacts readily with paraformaldehyde to give an intermediate mixture of mono- and dimethylol derivatives which upon heating forms the α-methylene derivatives of the oxazoline.The latter, upon acid hydrolysis, yields the α-substituted acrylic acid generally in an overall yield of above 70percent and the acids are usually at least 95percent pure.