136092-76-7 Usage
Description
(2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-4-enoic acid is a chiral organic compound with a pent-4-enoic acid backbone, featuring a methyl group, a carbonyl group, and an amino group attached to the structure. The "S" configuration denotes the specific orientation of the functional groups around the chiral center, which may contribute to its unique chemical and biological properties.
Uses
Used in Organic Synthesis:
(2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-4-enoic acid is used as a building block in organic synthesis for the creation of more complex molecules with potential applications in various industries.
Used in Pharmaceutical Development:
Due to its unique chemical structure, (2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-4-enoic acid is used as a starting material or intermediate in the development of new pharmaceutical compounds, potentially leading to the discovery of novel drugs with specific therapeutic effects.
Used in Biomedical Research:
(2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-4-enoic acid is utilized in biomedical research to study its interactions with biological systems, which may reveal insights into its potential biological activity and applications in medicine.
Further research and testing are required to fully understand the specific properties and potential uses of (2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-4-enoic acid in these applications.
Check Digit Verification of cas no
The CAS Registry Mumber 136092-76-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,0,9 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 136092-76:
(8*1)+(7*3)+(6*6)+(5*0)+(4*9)+(3*2)+(2*7)+(1*6)=127
127 % 10 = 7
So 136092-76-7 is a valid CAS Registry Number.
136092-76-7Relevant articles and documents
Design, Synthesis, and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents
Koike, Kota,Nagano, Masanobu,Ebihara, Masahiro,Hirayama, Tasuku,Tsuji, Mieko,Suga, Hiroaki,Nagasawa, Hideko
, p. 4022 - 4046 (2020/06/08)
By carrying out structural modifications based on the bicyclic peptide structure of echinomycin, we successfully synthesized various powerful antitumor derivatives. The ring conformation in the obtained compounds was restricted by cross-linking with an unnatural bond. The prepared derivatives were demonstrated to strongly suppress the hypoxia inducible factor (HIF)-1 transcriptional activation and hypoxia induction of HIF-1 protein expression. Particularly, alkene-bridged derivative 12 exhibited remarkably potent cytotoxicity (IC50 = 0.22 nM on the MCF-7 cell line) and HIF-1 inhibition (IC50 = 0.09 nM), which considerably exceeded those of echinomycin. Conformational analyses and molecular modeling studies revealed that the biological activities were enhanced following restriction of the conformation by cross-linking through a metabolically stable and rigid bridge bond. In addition, we proposed a new globular conformation stabilized by intramolecular πstacking that can contribute to the biological effects of bicyclic depsipeptides. The developments presented in the current study serve as a useful guide to expand the chemical space of peptides in drug discovery.
