1361013-62-8

Basic information

• Product Name: 5'-(4,4'-dimethoxytrityl)-4-N-benzoyl-5-formyl-2'-deoxycytidine
• Synonyms: 5'-(4,4'-dimethoxytrityl)-4-N-benzoyl-5-formyl-2'-deoxycytidine
• CAS NO: 1361013-62-8
• Molecular Weight: 661.711
• Mol File: 1361013-62-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-(4,4'-dimethoxytrityl)-4-N-benzoyl-5-formyl-2'-deoxycytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-(4,4'-dimethoxytrityl)-4-N-benzoyl-5-formyl-2'-deoxycytidine(1361013-62-8)
• EPA Substance Registry System: 5'-(4,4'-dimethoxytrityl)-4-N-benzoyl-5-formyl-2'-deoxycytidine(1361013-62-8)

Safety Data

• Hazardous Substances Data: 1361013-62-8(Hazardous Substances Data)

Upstream product

• 137017-45-9 5-formyl-2′-deoxycytidine 
• 838-07-3 5-methyldeoxycytidine 
• 478843-96-8 5-iodo-3'O,5'O-bis(tert-butyldimethylsilyl)-2'-deoxycytidine 
• 1361013-59-3 4-N-benzoyl-5-formyl-2'deoxycytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1361013-57-1 3',5'-(tert-butyldimethylsilyl)-4-N-benzoyl-5-formyl-2'deoxycytidine 
• 1257247-38-3 5-formyl-3′,5′-bis-(tert-butyl-dimethylsilyl)-2′-deoxy-cytidine 

Downstream Products

• 1361013-60-6 3'-(diisopropylamino-cyanoethoxyphosphino)-5'-(4,4'-dimethoxytrityl)-4-N-benzoyl-5-formyl-2'deoxycytidine 

Relevant articles and documents

5-Hydroxymethylcytosine and 5-formylcytosine containing deoxyoligonucleotides: Facile syntheses and melting temperature studies

An oxidation-based synthetic approach was developed for facile preparation of 5-formyl-2′-deoxycytidine and 5-hydroxymethyl-2′-deoxycytidine phosphoramidites. Upon introducing organic solvent components and copper catalysts, C5-methyl groups of 5-methyl-2′-deoxycytidine and thymidine were readily oxidized to formyl and hydroxyl functionality, respectively. Standard solid phase DNA synthesis and conventional deprotection methods were applicable to synthesize 5-formyl- or 5-hydroxymethyl-cytosine containing DNA oligonucleotides, which were used to study the effect of epigenetic modifications on DNA thermal dynamic stability.