1361236-71-6

Basic information

• Product Name: C₂₀H₁₅F₄N₃O₅S₂
• CAS NO: 1361236-71-6
• Molecular Weight: 517.482
• Mol File: 1361236-71-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₅F₄N₃O₅S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₅F₄N₃O₅S₂(1361236-71-6)
• EPA Substance Registry System: C₂₀H₁₅F₄N₃O₅S₂(1361236-71-6)

Safety Data

• Hazardous Substances Data: 1361236-71-6(Hazardous Substances Data)

Upstream product

• 16588-06-0 4-chloro-3-nitrobenzamide 
• 939-80-0 4-chloro-3-nitrobenzonitrile 
• 1361237-13-9 C₁₂H₇F₃N₂O₆S₂ 
• 90389-84-7 1-(3-fluorophenyl)-N-methylmethanamine 
• 1361237-03-7 C₁₄H₁₁F₃N₂O₆S₂ 
• 1361236-92-1 C₁₄H₁₁F₃N₂O₄S₂ 
• 1361236-82-9 C₁₃H₈ClF₃N₂O₄S 
• 871933-36-7 4-chloro-3-nitrobenzenecarbothioamide 

Relevant articles and documents

Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors

We previously identified a series of methylsulfonylnitrobenzoates (MSNBs) that block the interaction of the thyroid hormone receptor with its coactivators. MSNBs inhibit coactivator binding through irreversible modification of cysteine 298 of the thyroid hormone receptor (TR). Although MSNBs have better pharmacological features than our first generation inhibitors (β-aminoketones), they contain a potentially unstable ester linkage. Here we report the bioisosteric replacement of the ester linkage with a thiazole moiety, yielding sulfonylnitrophenylthiazoles (SNPTs). An array of SNPTs representing optimal side chains from the MSNB series was constructed using parallel chemistry and evaluated to test their antagonism of the TR-coactivator interaction. Selected active compounds were evaluated in secondary confirmatory assays including regulation of thyroid response element driven transcription in reporter constructs and native genes. In addition the selected SNPTs were shown to be selective for TR relative to other nuclear hormone receptors (NRs).