1361409-35-9Relevant articles and documents
Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy
Swahn, Britt-Marie,Holenz, J?rg,Kihlstr?m, Jacob,Kolmodin, Karin,Lindstr?m, Johan,Plobeck, Niklas,Rotticci, Didier,Sehgelmeble, Fernando,Sundstr?m, Marie,F?lting, Johanna,Georgievska, Biljana,Gustavsson, Susanne,Neelissen, Jan,Ek, Margareta,Olsson, Lise-Lotte,Berg, Stefan,Berg, Stefan Von
scheme or table, p. 1854 - 1859 (2012/04/17)
The evaluation of a series of bicyclic aminoimidazoles as potent BACE-1 inhibitors is described. The crystal structures of compounds 14 and 23 in complex with BACE-1 reveal hydrogen bond interactions with the protein important for achieving potent inhibit
