136175-17-2

Basic information

• Product Name: (2S,5S)-5-[(3S,5S)-1-Acetyl-5-(4-nitro-phenoxycarbonyl)-pyrrolidin-3-ylsulfanylmethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
• Synonyms: (2S,5S)-5-[(3S,5S)-1-Acetyl-5-(4-nitro-phenoxycarbonyl)-pyrrolidin-3-ylsulfanylmethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
• CAS NO: 136175-17-2
• Molecular Weight: 551.618
• Mol File: 136175-17-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,5S)-5-[(3S,5S)-1-Acetyl-5-(4-nitro-phenoxycarbonyl)-pyrrolidin-3-ylsulfanylmethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-5-[(3S,5S)-1-Acetyl-5-(4-nitro-phenoxycarbonyl)-pyrrolidin-3-ylsulfanylmethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester(136175-17-2)
• EPA Substance Registry System: (2S,5S)-5-[(3S,5S)-1-Acetyl-5-(4-nitro-phenoxycarbonyl)-pyrrolidin-3-ylsulfanylmethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester(136175-17-2)

Safety Data

• Hazardous Substances Data: 136175-17-2(Hazardous Substances Data)

Upstream product

• 136201-47-3 trans-1-(tert-Butoxycarbonyl)-2-carboxy-5-(ethoxycarbonyl)pyrroldine 
• 57750-51-3 (3R,5S)-5-(methoxycarbonyl)-1-acetylpyrrolidin-3-yl 4-methylbenzenesulfonate 
• 100895-61-2 N-acetyl-trans-4-(tosyloxy)-L-proline 
• 67943-19-5 methyl (2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 136235-07-9 Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine 
• 136175-14-9 (2R,5R)-5-Hydroxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 78854-25-8 C₇H₉NO₃S^(2-)*2Na⁽¹⁺⁾ 
• 136175-13-8 trans-1-(tert-Butoxycarbonyl)-2,5-bis(ethoxycarbonyl)pyrrolidine 
• 78854-23-6 N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid 
• 50990-25-5 estere etilico dell'acido 2,5-pirrolidincarbossilico trans 
• 90290-04-3 trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Studies of N-Terminal Templates for α-Helix Formation. Synthesis and Conformational Analysis of (2S,5S,8S,11S)-1-Acetyl-1,4-diaza-3-keto-5-carboxy-10-thiatricyclo4,8>tridecane (Ac-Hel1-OH)

A convergent synthesis of the title compound, a conformationally restricted analogue of acetyl-L-prolyl-L-proline, from 1-acetyl-2(S)-carboxy-4(S)-mercaptopyrrolidine and trans-1-(tert-butoxycarbonyl)-2(S)-(methoxycarbonyl)-5(S)-pyrrolidine (Ac-Hel1-OH) is reported, along with a synthesis of (2S,8S,11S)-1-acetyl-1,4-diaza-3-keto-10-thiatricyclo4,8>tridecane.In the crystal and in CDCl3 solution the conformation of Ac-Hel1-OH is shown to approximate a staggered orientation at the 8,9-CC bond and an s-cis orientation at the acetyl amide bond.In DMF, DMSO, MeCN, and D2O significant amounts of the s-trans conformer are also present.