136206-21-8

Basic information

• Product Name: 17β-(N-benzyloxycarbonyl-L-alanyl-L-seryl)aminoestra-1,3,5(10)-trien-3-ol
• CAS NO: 136206-21-8
• Molecular Weight: 563.694
• Mol File: 136206-21-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 17β-(N-benzyloxycarbonyl-L-alanyl-L-seryl)aminoestra-1,3,5(10)-trien-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-(N-benzyloxycarbonyl-L-alanyl-L-seryl)aminoestra-1,3,5(10)-trien-3-ol(136206-21-8)
• EPA Substance Registry System: 17β-(N-benzyloxycarbonyl-L-alanyl-L-seryl)aminoestra-1,3,5(10)-trien-3-ol(136206-21-8)

Safety Data

• Hazardous Substances Data: 136206-21-8(Hazardous Substances Data)

Upstream product

• 5982-51-4 3-hydroxy-estra-1,3,5⁽¹⁰⁾-trien-17-one oxime 
• 17460-58-1 (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-3-hydroxypropanoic acid 
• 20989-33-7 17β-amino-1,3,5(10)-estratrien-3-ol 

Relevant articles and documents

Synthesis of new amino acid and peptide derivatives of estradiol and their binding affinities for the estrogen receptor

A series of amino acid and peptide derivatives of estradiol have been synthesized by coupling 17β-aminoestra-1,3,5(10)-trien-3-ol, 17-hydrazonoestra-1,3,5(10)-trien-3-ol with amino acids or peptides, using tetrahydrothiazole-2-thione, N-hydroxy-1,4-epoxycyclohex-5-ene-2,3-dicarbonylimide, benzotriazolyloxy-tris(dimethylamino)phosphonium hexafluorophosphate, and p-nitrophenol as reagents.N-protected peptidyl steroids were deprotected by traditional methods.The relative binding affinities of the deprotected derivatives to the estrogen receptor were determined by competitive radioligand binding assay.Keywords: 17β-aminoestradiol derivatives; 17-hydrazonoestrone derivatives; amino acids; peptides; binding affinity; estrogen receptor; steroids