1363621-26-4

Basic information

• Product Name: ethyl 5-amino-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate
• Synonyms: ethyl 5-amino-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate
• CAS NO: 1363621-26-4
• Molecular Weight: 407.253
• Mol File: 1363621-26-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 5-amino-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-amino-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate(1363621-26-4)
• EPA Substance Registry System: ethyl 5-amino-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate(1363621-26-4)

Safety Data

• Hazardous Substances Data: 1363621-26-4(Hazardous Substances Data)

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 149288-99-3 ethyl 4-(2,6-dichlorobenzyloxy)benzoate 
• 149289-09-8 4-(2,6-dichlorobenzyloxy)benzoic acid 
• 1160250-95-2 4-(2,6-dichlorobenzyloxy)benzoyl chloride 
• 37842-58-3 1-cyano-2-ethoxy-2-oxoethanaminium 4-methylbenzenesulfonate 
• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 3849-21-6 ethyl cyanoglyoxylate-2-oxime 
• 32683-02-6 ethyl-2-aminocyano acetate 

Downstream Products

• 1363621-28-6 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylic acid 
• 1363621-27-5 ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate 

Relevant articles and documents

Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2

A series of substituted 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives were synthesized. The derivatives were screened for in vitro anti-tubercular activities against Mycobacterium tuberculosis H37Rv using the Microplate Alamar Blue Assay (MABA), and antibacterial activities with agar dilution method against clinical S. aureus, E. coli, S. pneumoniae and penicilin-resistant S. pneumoniae. Among 15 compounds, several thiazole derivatives exhibited good anti-tubercular activities with MIC values between 1 μM and 61.2 μM, and potent activities against S. pneumoniae with MIC values less than 0.134 μM. These studies suggest that the thiazole scaffold may serve as a new promising template for further elaboration as anti-tubercular and antibacterial drugs.