1363792-20-4

Basic information

• Product Name: 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate
• Synonyms: 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate
• CAS NO: 1363792-20-4
• Molecular Weight: 411.675
• Mol File: 1363792-20-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate(1363792-20-4)
• EPA Substance Registry System: 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate(1363792-20-4)

Safety Data

• Hazardous Substances Data: 1363792-20-4(Hazardous Substances Data)

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 178172-70-8 (±)-1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethanol 
• 159178-03-7 2,6-dichloro-4-isocyanatopyridine 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 

Relevant articles and documents

Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)- 1-phenylethanol derivatives

A new series of aromatic ester and carbamate derivatives of 2-(1H-imidazol-1-yl)-1-phenylethanol were synthesized and evaluated for their antifungal activity towards Candida albicans and non-albicans Candida species strains. The aromatic biphenyl ester derivatives 6a-c were more active than the reference compound fluconazole. 6c possesses a MIC mean values of 1.7 ± 1.4 μg mL-1 vs C. albicans and 1.9 ± 2.0 μg mL -1 vs non-albicans Candida species strains. The racemic mixtures of 6a, b were purified to afford the pure enantiomers. The (-) isomers were up to 500 times more active than (+) isomers. (-)-6a and (-)-6b were thirty and ninety times more active than fluconazole towards C. krusei strain respectively. The racemates of 6a-c showed low cytotoxicity against human monocytic cell line (U937) with 6a demonstrating a CC50 greater than 128 μg mL -1.