136401-70-2 Usage
General Description
5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione is a complex synthetic chemical compound. The chemistry of this compound is characterized by various functional groups such as Ethylpyridinyl, Ethoxy, Benzylidene, and Thiazolidinedione. It belongs to the organic class of compounds known as benzylideneanilines, which are characterized by an aniline group substituted at the benzene ring by a benzylidene moiety. Thiazolidinedione, another major functional group present, correlates with its potential biological activity. However, detailed information regarding its physical characteristics, chemical stability, potential uses, or biological activity is not readily available, indicating that this could be a novel compound under investigation.
Check Digit Verification of cas no
The CAS Registry Mumber 136401-70-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,4,0 and 1 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 136401-70:
(8*1)+(7*3)+(6*6)+(5*4)+(4*0)+(3*1)+(2*7)+(1*0)=102
102 % 10 = 2
So 136401-70-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H18N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,11-12H,2,9-10H2,1H3,(H,21,22,23)
136401-70-2Relevant articles and documents
Studies on antidiabetic agents. X. Synthesis and biological activities of pioglitazone and related compounds
Momose,Meguro,Ikeda,Hatanaka,Oi,Sohda
, p. 1440 - 1445 (2007/10/02)
Various analogues of a new antidiabetic agent, pioglitazone (AD-4833, U-72107), were synthesized in order to study in more detail the structure-activity relationships of this class of drug. 5-(4-Pyridylalkylthiobenzyl)-2,4-thiazolidinediones (I), this-analogues of pioglitazone, were prepared via Meerwein arylation of the alkylthioanilines (IV). 5-(4-Pyridylalkoxybenzylidene)-2,4-thiazolidinediones (IIa) and related heterocyclic analogues (IIb) were synthesized by Knoevenagel condensation of the aldehydes (VIII) with the corresponding azolidinones. Compounds I and II were evaluated for hypoglycemic and hypolipidemic activity in genetically obese and diabetic yellow KK (KKA(y)) mice. Several 5-[4-[2-(2-pyridyl)ethoxy]-benzylidene]-2,4-thiazolidinediones (IIa) were equipotent to pioglitazone. However, the thia-analogues (I) and the benzylideneheterocycles (IIb) had decreased activity. Catalytic hydrogenation of the 5-benzylidene analogue (14) was found to be a convenient new synthetic method for pioglitazone. The configuration of 14 is also discussed.