136413-17-7Relevant articles and documents
Preparation of bifunctional isocyanate hydroxamate linkers: Synthesis of carbamate and urea tethered polyhydroxamic acid chelators
Fernando, Rasika,Shirley, Jonathan M.,Torres, Emilio,Jacobs, Hollie K.,Gopalan, Aravamudan S.
, p. 6367 - 6371,5 (2012/12/12)
Two novel bifunctional N-methylhydroxamate-isocyanate linkers 20 and 21 were prepared in good yield and high purity from the corresponding amine salts using a biphasic reaction with phosgene. The facile ring opening reaction of N-Boc lactams using the anion of O-benzylhydroxylamine gave the protected amino hydroxamates 6a and 6c in good yields. The selective methylation of the hydroxamate nitrogen in the presence of the N-Boc group in these intermediates could be readily accomplished. The utility of the linkers was clearly demonstrated by the synthesis of the carbamate-tethered trishydroxamic acid 27 and the urea-tethered 29.
N-Hydroxy Amides. Part 9. Synthesis and Iron(III) Complexes of Tripodal Hydroxamic Acids derived from ω-(N-Hydroxyamino)alkanoic Acids and Tris-(2-aminoethyl)amine
Katoh, Akira,Akiyama, Masayasu
, p. 1839 - 1842 (2007/10/02)
Tripodal oligoamide hydroxamic acids with different chain lengths (compound 8a-d) are prepared via condensation of N-hydroxysuccinimide esters of N-acyl-N-benzyloxyaminoalkanoic acids with tris-(2-aminoethyl)amine.These synthetic trihydroxamic acids form
