136425-03-1

Basic information

• Product Name: Ethyl 4,4,4-trifluoro-2-<2-(1-cyclohexenyl)ethyl>-2-methyl-3-oxobutanoate
• CAS NO: 136425-03-1
• Molecular Weight: 306.325
• Mol File: 136425-03-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethyl 4,4,4-trifluoro-2-<2-(1-cyclohexenyl)ethyl>-2-methyl-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4,4,4-trifluoro-2-<2-(1-cyclohexenyl)ethyl>-2-methyl-3-oxobutanoate(136425-03-1)
• EPA Substance Registry System: Ethyl 4,4,4-trifluoro-2-<2-(1-cyclohexenyl)ethyl>-2-methyl-3-oxobutanoate(136425-03-1)

Safety Data

• Hazardous Substances Data: 136425-03-1(Hazardous Substances Data)

Upstream product

• 932-86-5 (2-bromoethylidene)cyclohexane 
• 344-00-3 ethyl 2-methyl-4,4,4-trifluoroacetoacetate 
• 136425-04-2 2-(2-Cyclohexylidene-ethyl)-4,4,4-trifluoro-2-methyl-3-oxo-butyric acid ethyl ester 

Relevant articles and documents

Lewis Acis Induced Ene Cyclization of ω-Olefinic Trifluoromethyl Ketones: Access to BIcyclic Compounds Bearing a CF3 Group

Lewis acid induced ene cyclization of ω-olefinic trifluoromethyl ketones provides (trifluoromethyl)decalins and (trifluoromethyl)hydrindans in high yield. δ-(1-Cyclohexenyl) trifluoromethyl ketone 1a leads stereoselectively to 1-(trifluoromethyl)-1-hydroxy-Δ5,10-octalin 3a or 10-chloro-1-(trifluoromethyl)-1-hydroxydecalin 6a, depending on the choice of Lewis acid. γ-(1-Cyclohexenyl) trifluoromethyl ketone 2a leads to a mixture of 9-chloro-1-(trifluoromethyl)-1-hydroxyhydrindans 10a and 11a.Similar reactions were performed successfully with the corresponding β-keto esters 1b and 2b.