136450-11-8Relevant articles and documents
Industrial preparation method of anti-asthma drug pranlukast intermediate
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Paragraph 0015-0020; 0022; 0024, (2020/04/17)
The invention discloses a preparation method of a pranlukast intermediate N-(2-cyano-4-oxo-4H-chromene-8-yl)-4-(4-butoxyphenyl)benzamide (short for formula I), specifically a method for preparing N-(2-cyano-4-oxo-4H-chromene-8-yl)-4-(4-butoxyphenyl)benzamide by carrying out a dewatering reaction on 4-oxo-8-[4-(4-butoxyphenyl)benzamide]-4H-chromene-2-formamide (short for formula II). The preparation method of the pranlukast intermediate represented by the formula I is high in yield, good in product color, high in product purity and beneficial to industrial production.
A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists
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Page/Page column 7, (2010/11/30)
A process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or -NHCOR1 group, wherein R1 is C1-C6 alkyl or phenyl optionally substituted by a -O-(CH2)su
PROCESS FOR PRODUCING NITRILE COMPOUND
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Page 4, (2008/06/13)
Processes for the preparation of the nitrile compound of formula (1). According to the present invention, the compound of formula (I) can be prepared cheaply and simply, therefore, the present invention is excellent as the industrial mass production metho