1364933-59-4 Usage
Description
JWH 412 is a positional isomer of AM2201, a naphthoylindole compound that acts on cannabinoid receptors. It was identified in the 'herbal mixture' XoXo and is characterized by its enhanced binding affinity to the central cannabinoid (CB1) receptor due to the substitution of hydrogen with fluorine in the 4-position of the naphthyl moiety. JWH 412 exhibits Ki values of 7.2 nM at CB1 and 3.2 nM at peripheral CB2 receptors. JWH 412 is primarily intended for research and forensic purposes.
Uses
Used in Research and Forensic Applications:
JWH 412 is used as a research compound for studying the interactions and effects of cannabinoids on the CB1 and CB2 receptors. Its enhanced binding affinity compared to other cannabinoids makes it a valuable tool in understanding the mechanisms of cannabinoid action and developing potential therapeutic applications.
Used in Pharmaceutical Development:
JWH 412's high affinity for cannabinoid receptors makes it a potential candidate for the development of new pharmaceuticals targeting these receptors. It can be used in the design and synthesis of novel cannabinoid-based drugs for various medical conditions, including pain management, inflammation, and neurological disorders.
Used in Analytical Chemistry:
The identification of JWH 412 in 'herbal mixtures' highlights its use in analytical chemistry for the detection and analysis of synthetic cannabinoids in various samples. This can be crucial in forensic investigations and the regulation of these substances.
Used in Toxicology Studies:
JWH 412 can be employed in toxicology research to investigate the potential risks and side effects associated with the use of synthetic cannabinoids. This information is essential for understanding the safety profile of these compounds and informing regulatory decisions.
Check Digit Verification of cas no
The CAS Registry Mumber 1364933-59-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,4,9,3 and 3 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1364933-59:
(9*1)+(8*3)+(7*6)+(6*4)+(5*9)+(4*3)+(3*3)+(2*5)+(1*9)=184
184 % 10 = 4
So 1364933-59-4 is a valid CAS Registry Number.
1364933-59-4Relevant articles and documents
Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents
Wiley, Jenny L.,Smith, Valerie J.,Chen, Jianhong,Martin, Billy R.,Huffman, John W.
, p. 2067 - 2081 (2012/06/01)
To develop SAR at both the cannabinoid CB1 and CB2 receptors for 3-(1-naphthoyl)indoles bearing moderately electron withdrawing substituents at C-4 of the naphthoyl moiety, 1-propyl and 1-pentyl-3-(4-fluoro, chloro, bromo and iodo-1-naphthoyl) derivatives were prepared. To study the steric and electronic effects of substituents at the 8-position of the naphthoyl group, the 3-(4-chloro, bromo and iodo-1-naphthoyl)indoles were also synthesized. The affinities of both groups of compounds for the CB1 and CB2 receptors were determined and several of them were evaluated in vivo in the mouse. The effects of these substituents on receptor affinities and in vivo activity are discussed and structure-activity relationships are presented. Although many of these compounds are selective for the CB2 receptor, only three JWH-423, 1-propyl-3-(4-iodo-1-naphthoyl)indole, JWH-422, 2-methyl-1-propyl-3-(4-iodo-1-naphthoyl)indole, the 2-methyl analog of JWH-423 and JWH-417, 1-pentyl-3-(8-iodo-1-naphthoyl)indole, possess the desirable combination of low CB1 affinity and good CB2 affinity.
