13650-70-9Relevant articles and documents
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Shemyakin,M.M. et al.
, (1966)
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Total Synthesis of (+)-Prunustatin A: Utility of Organotrifluoroborate-Mediated Prenylation and Shiina MNBA Esterification and Macrolactonization to Avoid a Competing Thorpe-Ingold Effect Accelerated Transesterification
Chojnacka, Maja W.,Batey, Robert A.
supporting information, p. 5671 - 5675 (2018/09/13)
A convergent total synthesis of (+)-prunustatin A is described through the assembly of two key fragments and a macrolactonization. Shiina MNBA couplings were used for the formation of each of the four ester bonds in the tetralactone ring, including the key macrocyclization which was essential to minimize competing Thorpe-Ingold accelerated transesterification. Other key steps included an organoboron-based prenylation using potassium prenyltrifluoroborate and a carbonyldiimidazole-mediated coupling to form the salicylamide.
METHODS AND COMPOSITIONS FOR PREVENTING OPIOID ABUSE
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Paragraph 0705; 0708, (2016/11/28)
Abuse-resistant opioid compounds, drug delivery systems, pharmaceutical compositions comprising an opioid covalently bound to a chemical moiety are provided. Methods of delivering an active ingredient to a subject and methods of preventing opioid abuse are also provided.
Total synthesis of carolacton, a highly potent biofilm inhibitor
Schmidt, Thomas,Kirschning, Andreas
supporting information; experimental part, p. 1063 - 1066 (2012/03/11)
Metals are the key players in the synthesis of caralacton, a strong inhibitor of bacterial biofilms. The total synthesis is based on several metal-mediated key transformations such as the Ley and the Duthaler-Hafner aldol reactions, the Marshall reaction and Breit's substitution, as well as the Nozaki-Hiyama-Kishi and Negishi-Fu C-C coupling reactions. Copyright