136516-64-8

Basic information

• Product Name: Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)
• Synonyms: Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI);4,6-Difluoro-2-hydroxybenzaldehyde;Benzaldehyde, 2,4-difluoro-6-hydroxy-
• CAS NO: 136516-64-8
• Molecular Formula: C₇H₄F₂O₂
• Molecular Weight: 158.1022664
• EINECS: 1533716-785-6
• Product Categories: ALDEHYDE
• Mol File: 136516-64-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 32℃
• Boiling Point: 207.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.464±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.18±0.15(Predicted)
• CAS DataBase Reference: Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)(136516-64-8)
• EPA Substance Registry System: Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)(136516-64-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 136516-64-8(Hazardous Substances Data)

Usage

General Description

Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI) is a chemical compound with the molecular formula C7H4F2O2. It is an organic compound that is commonly used in the manufacturing of various products such as dyes, perfumes, and flavorings. Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI) is known for its aromatic and sweet almond-like odor, and it is used as a flavoring agent in the food industry. Additionally, it has been studied for its potential pharmaceutical applications, particularly as a building block in the synthesis of various drug molecules. However, the compound also poses potential health hazards if not handled properly, and exposure to high levels of benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI) can cause irritation to the eyes, skin, and respiratory system.

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 899427-17-9 (3,5-difluorophenyl) N-isopropylcarbamate 
• 608515-57-7 2,4-difluoro-6-methoxybenzaldehyde 
• 50-00-0 formaldehyd 
• 2713-34-0 3,5-difluorophenol 

Downstream Products

• 608515-58-8 2,4-difluoro-6-prop-1-ynylbenzaldehyde 
• 1209492-98-7 2-(allyloxy)-4,6-difluorobenzaldehyde 
• 1446332-82-6 tert-butyl 4-(3-(3,5-difluorophenyl)-5-fluoro-2-oxo-2H-chromen-7-yl)piperazine-1-carboxylate 
• 1446330-28-4 3-(3,5-difluorophenyl)-5-fluoro-7-(piperazin-1-yl)-2H-chromen-2-one 
• 1446332-78-0 tert-butyl 4-(3-fluoro-4-formyl-5-hydroxyphenyl)piperazine-1-carboxylate 

Relevant articles and documents

Efficient two-step synthesis of salicylaldehydes via directed ortho-lithiation of in situ N-silylated O-aryl N-isopropylcarbamates

O-Aryl N-isopropylcarbamates, conveniently prepared from phenols and isopropyl isocyanate, are subjected to an efficient ortho-lithiation protocol to afford the corresponding salicylaldehydes in a one-pot operation in high yields. Georg Thieme Verlag Stuttgart.

Compounds for treating spinal muscular atrophy

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Structure based drug design: Development of potent and selective factor IXa (FIXa) inhibitor

On the basis of our understanding on the binding interactions of the benzothiophene template within the FIXa active site by X-ray crystallography and molecular modeling studies, we developed our SAR strategy by targeting the 4-position of the template to access the S1 β and S2-S4 sites. A number of highly selective and potent, factor Xa (FXa) and FIXa inhibitors were identified by simple switch of functional groups with conformational changes toward the S2-S4 sites.