136539-37-2

Basic information

• Product Name: 4-(4-Chloro-phenyl)-piperazine-1-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester
• CAS NO: 136539-37-2
• Molecular Weight: 615.085
• Mol File: 136539-37-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-Chloro-phenyl)-piperazine-1-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chloro-phenyl)-piperazine-1-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester(136539-37-2)
• EPA Substance Registry System: 4-(4-Chloro-phenyl)-piperazine-1-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester(136539-37-2)

Safety Data

• Hazardous Substances Data: 136539-37-2(Hazardous Substances Data)

Upstream product

• 7689-03-4 camptothecin 
• 86639-51-2 7-Ethylcamptothecin 1-Oxide 
• 86639-52-3 7-ethyl-10-hydroxycamptothecin 
• 78287-27-1 7-ethylcamptothecin 
• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 97682-31-0 7-Ethyl-10-chlorocarbonyloxycamptothecin 

Relevant articles and documents

Synthesis and antitumor activity of 20(S)-camptothecin derivatives: Carbamate-linked, water-soluble derivatives of 7-ethyl-10-hydroxycamptothecin

Novel 36 derivatives (6), bonding the phenolic hydroxyl group of 7-ethyl-10-hydroxycamptothecin (4) with diamines through a monocarbamate linkage, were synthesized and their antitumor activity was evaluated in vivo. The derivatives were soluble in water as their HCl salts with the E lactone ring intact and exhibited significant antitumor activity. One of the derivatives, 6-27 showed excellent activity against L1210 leukemia and other murine tumors. The structure of its hydrochloride trihydrate (CPT-11) was determined by spectroscopic and crystallographic methods.