1365565-86-1

Basic information

• Product Name: 2-(2-chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• Synonyms: 2-(2-chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 1365565-86-1
• Molecular Weight: 252.549
• Mol File: 1365565-86-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(2-chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(1365565-86-1)
• EPA Substance Registry System: 2-(2-chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(1365565-86-1)

Safety Data

• Hazardous Substances Data: 1365565-86-1(Hazardous Substances Data)

Upstream product

• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 13826-27-2 2,2'-bis(1,3,2-benzodioxaborole) 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 73183-34-3 bis(pinacol)diborane 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 66107-36-6 2-chlorophenyl triflate 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 

Downstream Products

• 2444-36-2 2'-chloro-benzeneacetic acid 

Relevant articles and documents

Photochemical Radical C–H Halogenation of Benzyl N-Methyliminodiacetyl (MIDA) Boronates: Synthesis of α-Functionalized Alkyl Boronates

α-Haloboronates are useful organic synthons that can be converted to a diverse array of α-substituted alkyl borons. Methods to α-haloboronates are limiting and often suffer from harsh reaction conditions. Reported herein is a photochemical radical C-H halogenation of benzyl N-methyliminodiacetyl (MIDA) boronates. Fluorination, chlorination, and bromination reactions were effective by using this protocol. Upon reaction with different nucleophiles, the C?Br bond in the brominated product could be readily transformed to a series of C?C, C?O, C?N, C?S, C?P, and C?I bonds, some of which are difficult to forge with α-halo sp2-B boronate esters. An activation effect of B(MIDA) moiety was found.

Isoquinolone compound and application thereof

The invention relates to an isoquinolone compound and application thereof. The invention in particular relates to an isoquinolone compound used as a HIF prolyl hydroxylase inhibitor (HIF-PHI) and a pharmaceutical composition thereof. Moreover, the present invention provides the application of the isoquinolinone compound or the pharmaceutical composition thereof in the preparation of a medicament for preventing or treating HIF-associated or HIF-mediated diseases as anemia or ischemia, local ischemia or hypoxia.

Preparation method of benzyl boron ester compound

The invention discloses a preparation method of a benzyl boron ester compound. According to the preparation method, aromatic boric acid Ar-B(OH)2, trimethyl silicon-based diazomethane, pinacol and tetrabutyl ammonium fluoride are subjected to a reaction in an organic solvent so as to obtain a benzyl pinacol boron ester compound, wherein Ar represents a non-heterocyclic aromatic group. After the method is adopted, the benzyl boron ester compound is obtained by starting from the aromatic boric acid and converting under a one-pot condition; the method is mild in reaction conditions, the reaction related to the method occurs smoothly in the air without needing strict water-free and oxygen-free conditions, and the method is convenient and simple to operate; the method has better tolerance and universality for functional groups and does not need an expensive metal catalyst and a ligand, thus being lower in reaction cost and being widely used for preparing the benzyl boron ester compound.