136564-68-6

Basic information

• Product Name: (R)-3-Methoxy-4-[1-methyl-5-[N-(2-methyl-4,4,4-trifluorobutyl)carbamoyl]indol-3-ylmethyl]-N-(2-methylphenylsulfonyl)benzamide
• Synonyms: ZD-3523; (R)-3-[2-Methoxy-4-[N-(2-methylphenylsulfonyl)carbamoyl]benzyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)indole-5-carboxamide; 3-(2-methoxy-4-{[(2-methylphenyl)sulfonyl]carbamoyl}benzyl)-1-methyl-N-[(2R)-4,4,4-trifluoro-2-methylbutyl]-1H-indole-5-carboxamide; Zeneca ZD 3523; Masilukast
• CAS NO: 136564-68-6
• Molecular Formula: C₃₁H₃₂F₃N₃O₅S
• Molecular Weight: 615.6631
• Mol File: 136564-68-6.mol
• Article Data: 2

Chemical Properties

• Density: 1.31g/cm³
• Refractive Index: 1.587
• CAS DataBase Reference: (R)-3-Methoxy-4-[1-methyl-5-[N-(2-methyl-4,4,4-trifluorobutyl)carbamoyl]indol-3-ylmethyl]-N-(2-methylphenylsulfonyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Methoxy-4-[1-methyl-5-[N-(2-methyl-4,4,4-trifluorobutyl)carbamoyl]indol-3-ylmethyl]-N-(2-methylphenylsulfonyl)benzamide(136564-68-6)
• EPA Substance Registry System: (R)-3-Methoxy-4-[1-methyl-5-[N-(2-methyl-4,4,4-trifluorobutyl)carbamoyl]indol-3-ylmethyl]-N-(2-methylphenylsulfonyl)benzamide(136564-68-6)

Safety Data

• Hazardous Substances Data: 136564-68-6(Hazardous Substances Data)

Usage

General Description

"(R)-3-Methoxy-4-[1-methyl-5-[N-(2-methyl-4,4,4-trifluorobutyl)carbamoyl]indol-3-ylmethyl]-N-(2-methylphenylsulfonyl)benzamide" is a complex organic compound. It is characterized by several functional groups, including a methoxy group, a carbamoyl group, a trifluorobutyl group, a benzamide group, and a sulfonyl group. It also includes two different types of aromatic systems, an indole ring and a phenyl ring. The compound's chirality is specified by the (R)-configuration, which indicates the spatial arrangement of the different groups around the chiral center. The exact physical and chemical properties of this compound, such as its melting point, boiling point, solubility, and reactivity, would depend on its specific structure and would need to be determined experimentally.

Upstream product

• 88-19-7 methyl 2-(aminosulfonyl)benzoate 
• 136564-79-9 (R)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid 
• 136564-73-3 methyl 4-<<5-carboxy-1-methylindol-3-yl>methyl>-3-methoxybenzoate 
• 136564-83-5 (R)-2-methyl-4,4,4-trifluorobutylamine hydrochloride 
• 136564-84-6 methyl (R)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoate 

Downstream Products

• 143484-12-2 4-(5-methoxycarbonyl-1-methylindol-3-ylmethyl)-3-methoxybenzoyl chloride 
• 143484-03-1 methyl 4-(5-methoxycarbonylindol-3-ylmethyl)-3-methoxybenzoate 

Relevant articles and documents

Pharmaceutical agents

A physical form of (R)-3-methoxy-4-[1-methyl-5-(2-methyl-4,4,4-trifluorobutylcarbamoyl)indol -3-ylmethyl]-N-(2-methylphenylsulphonyl)benzamide substantially free of other physical forms, which form is crystalline and has an X-ray powder diffraction pattern with specific peaks at 2θ=14.0, 19.4, 22.0, 22.4 and 24.7° , processes for preparing the form and pharmaceutical compositions containing it. The compound is a leukotriene antagonist useful in the treatment of diseases such as asthma.