1365842-01-8Relevant articles and documents
Nickel-catalyzed negishi alkylations of styrenyl aziridines
Huang, Chung-Yang,Doyle, Abigail G.
, p. 9541 - 9544 (2012/07/14)
A nickel-catalyzed cross-coupling reaction between N-sulfonyl aziridines and organozinc reagents is reported. The catalytic system comprises an inexpensive and air-stable Ni(II) source and dimethyl fumarate as ligand. Regioselective synthesis of β-substituted amines is possible under mild and functional-group-tolerant conditions. The stereoselectivity of the reaction is consistent with a stereoconvergent mechanism wherein the sulfonamide directs C-C bond formation.