1366234-66-3

Basic information

• Product Name: ((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane)
• Synonyms: ((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane)
• CAS NO: 1366234-66-3
• Molecular Weight: 464.601
• Mol File: 1366234-66-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane)(CAS DataBase Reference)
• NIST Chemistry Reference: ((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane)(1366234-66-3)
• EPA Substance Registry System: ((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane)(1366234-66-3)

Safety Data

• Hazardous Substances Data: 1366234-66-3(Hazardous Substances Data)

Upstream product

• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 181225-39-8 ((5-bromo-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane) 
• 120951-86-2 1,3-O-bis(tert-butyldimethylsilyl)resorcinol 
• 73183-34-3 bis(pinacol)diborane 
• 108-46-3 recorcinol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1443526-60-0 (E)-ethyl 4-(3',5'-bis((tert-butyldimethylsilyl)oxy)-3-methoxy-4-(tosyloxy)-[1,10-biphenyl]-2-yl)-2-methylbut-2-enoate 
• 1352571-66-4 4-(4-methoxybenzyloxy)-5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(tetrahydro-2H-pyran-4-yloxy)phenyl)pyrimidine 
• 1352570-48-9 5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(tetrahydro-2H-pyran-4-yloxy)phenyl)pyrimidin-4(3H)-one 
• 1352570-45-6 5-methyl-2-{3-[4-(methylsulfonyl)phenoxy]-5-(tetrahydrofuran-3-yloxy)phenyl}pyrimidin-4(3H)-one 
• 1352571-41-5 3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol 
• 1352571-40-4 5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)benzene-1,3-diol 
• 1352571-55-1 (+/-)-3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(tetrahydrofuran-3-yloxy)phenol 
• 1352571-39-1 2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine 

Relevant articles and documents

NOVEL COMPOUNDS AND THERAPEUTICS USES THEREOF

The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, processes for their preparation and to novel intermediates used in said process.

COMPOUNDS AND THERAPEUTIC USES THEREOF

The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and a disease or disorder mediated and/or caused by an infective agent, to compositions containing said compounds, processes for their preparation and to novel intermediates used in said process.

2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES

O N NH R3 R2 O R1 168 ABSTRACT The present invention provides a 2-(3,5-disubstitutedphenyl)pyrimidin- 4(3H)-one compound of Formula (I) 5 (I) or a pharmaceutically acceptable salt thereof wherein R 1, R2 and R3 are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and 10 the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.