136631-80-6

Basic information

• Product Name: (R)-[(R)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-phenyl-acetic acid ethyl ester
• Synonyms: (R)-[(R)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-phenyl-acetic acid ethyl ester
• CAS NO: 136631-80-6
• Molecular Weight: 465.549
• Mol File: 136631-80-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-[(R)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-phenyl-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-[(R)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-phenyl-acetic acid ethyl ester(136631-80-6)
• EPA Substance Registry System: (R)-[(R)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-phenyl-acetic acid ethyl ester(136631-80-6)

Safety Data

• Hazardous Substances Data: 136631-80-6(Hazardous Substances Data)

Upstream product

• 39251-40-6 (R)-amino-phenyl-acetic acid ethyl ester 
• 5241-64-5 Boc-D-Trp-OH 

Relevant articles and documents

Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors

The intriguing structural similarities of glutamic acid based cholecystokinin (CCK) antagonists (A-64718 and A-65186) and the benzodiazepine CCK antagonist MK-329 (L-364,718) have been reported. Efforts to include the weak CCK antagonist benzotript into this construct utilizing a similar approach have resulted in a novel series of benzotript-based hybrid antagonists N(α)-(3'-quinolylcarbonyl)-(R)-tryptophan di-n-pentylamide (9, A-67396), N(α)-(4',8'-dihydroxy-2'-quinolylcarbonyl)-(R)-tryptophan di-n-pentylamide (23, A-70276), and N(α)-(3'-quinolylcarbonyl)-(R)-5'-hydroxytryptophan di-n-pentylamide (36, A-71134) which possess respectively binding affinities of 23, 21, and 11 nM for the pancreatic CCK-A receptor and which inhibit CCK8-induced amylase secretion. Compound 9 possesses a selectivity of > 500-fold for the pancreatic CCK-A receptor over the CCK-B receptor.