1366591-26-5Relevant articles and documents
Regioselective Opening of Nitroepoxides with Unsymmetrical Diamines
Nosood, Yazdanbakhsh L.,Ziyaei Halimehjani, Azim,González, Florenci V.
, p. 1252 - 1258 (2018)
Nitroepoxides are easily transformed into benzodiazepines, tetrahydrobenzodiazepines, imidazopyridines, and N-alkyl tetrahydroquinoxalines by treatment with 2-aminobenzylamines, 2-aminopyridines, and N-alkyl 1,2-diaminobenzenes, respectively. Regioselectivity is controlled through attack of the most nucleophilic nitrogen of the unsymmetrical diamine to the β position of the epoxide. These reactions represent an efficient way to prepare privileged bioactive structures.
Cu-Pybox catalyzed synthesis of 2,3-disubstituted imidazo[1,2-a]pyridines from 2-aminopyridines and propargyl alcohol derivatives
Cheng, Cang,Ge, Luo,Lu, Xuehe,Huang, Jianping,Huang, Haocheng,Chen, Jie,Cao, Weiguo,Wu, Xiaoyu
, p. 6866 - 6874 (2016/10/04)
A highly efficient cascade sequence for syntheses of 2,3-disubstituted imidazo[1,2-a]pyridines with exclusive regioselectivity in moderate to excellent yields has been developed. This cascade was initiated through propargylation of 2-aminopyridines at pyridine-nitrogen with propargyl alcohol derivatives using Cu(II)-Pybox as catalyst and followed by an intramolecular cyclization and isomerization. Besides 2-aminopyridine, less reactive 2-aminopyrimidine, 2-aminopyrazine and 3-aminopyridazine were also suitable in this cascade.
Rhodium-catalyzed highly regioselective C-H arylation of imidazo[1,2-a]pyridines with aryl halides and triflates
Liu, Yi,He, Lin,Yin, Guoqiang,Wu, Guojie,Cui, Yingde
, p. 2340 - 2342 (2013/09/24)
A convenient Rh-catalyzed C-H arylation of imidazo[1,2-a]pyridines with a variety of aryl halides or triflates has been reported. This process afforded a range of biaryl compounds in excellent yields and showed high activity and broad scope.
