13668-21-8Relevant articles and documents
SYNTHESIS AND ANTI-ARRHYTHMIC ACTIVITY OF CYCLOALKANEINDOLES
Abou-Gharbia, Magid,Patel, Usha,Tokolics, Joseph,Freed, Meier
, p. 373 - 378 (2007/10/02)
A series of novel functionalized cycloalkaneindoles were synthesized and tested for potential anti-arrhythmic activity.Several compounds displayed moderate activity in the coronary ligated rat artery model.Carbamate 22 and the amino derivative 27 were the most potent analogs.Their anti-arrhythmic activity at a dose of 10 mg/kg, i.v., was greater than that of iprindole and ethmosin. anti-arrhythmic agents / ethmosin / carbamates / coronary ligated rats