1367177-22-7Relevant articles and documents
Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited rabggtase
Deraeve, Celine,Guo, Zhong,Bon, Robin S.,Blankenfeldt, Wulf,DiLucrezia, Raffaella,Wolf, Alexander,Menninger, Sascha,Stigter, E. Anouk,Wetzel, Stefan,Choidas, Axel,Alexandrov, Kirill,Waldmann, Herbert,Goody, Roger S.,Wu, Yao-Wen
, p. 7384 - 7391 (2012)
Post-translational attachment of geranylgeranyl isoprenoids to Rab GTPases, the key organizers of intracellular vesicular transport, is essential for their function. Rab geranylgeranyl transferase (RabGGTase) is responsible for prenylation of Rab proteins