1367349-47-0

Basic information

• Product Name: (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide
• Synonyms: (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide
• CAS NO: 1367349-47-0
• Molecular Weight: 419.452
• Mol File: 1367349-47-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide(1367349-47-0)
• EPA Substance Registry System: (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide(1367349-47-0)

Safety Data

• Hazardous Substances Data: 1367349-47-0(Hazardous Substances Data)

Upstream product

• 101209-08-9 4-acetamido-3-bromoacetophenone 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 1367349-48-1 (E)-1-(6-amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Synthesis and cytotoxicity evaluation of biaryl-based chalcones and their potential in TNFα-induced nuclear factor-κB activation inhibition

A series of biaryl-based chalcones were designed as a combination of the natural chalcone and biphenyl moieties, and synthesized by two step chemistry involving Knoevenagel reaction and microwave assistant Suzuki coupling. Sulforhodamine B (SRB) assay was performed to evaluate the cell viability inhibitory abilities of these compounds against five cancer cell lines (A549, CNE2, SW480, MCF-7, and HepG2) from different tissues. Their Nuclear Factor-κB (NF-κB) nuclear translocation inhibitory activities were further investigated by High Content Analysis (HCA) based assay. Most of the compounds showed moderate to strong anticancer and NF-κB nuclear translocation inhibition activities and potent compounds were found.