136741-51-0

Basic information

• Product Name: 6-Methoxy-3-phenyl-benzo[d]isoxazole
• Synonyms: 6-Methoxy-3-phenyl-benzo[d]isoxazole
• CAS NO: 136741-51-0
• Molecular Weight: 225.247
• Mol File: 136741-51-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-Methoxy-3-phenyl-benzo[d]isoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-3-phenyl-benzo[d]isoxazole(136741-51-0)
• EPA Substance Registry System: 6-Methoxy-3-phenyl-benzo[d]isoxazole(136741-51-0)

Safety Data

• Hazardous Substances Data: 136741-51-0(Hazardous Substances Data)

Upstream product

• 131-57-7 Benzophenone-3 
• 845266-67-3 2-[imino(phenyl)methyl]-5-methoxyphenol 
• 51674-04-5 2-hydroxyphenyl-4-methoxy-1-benzophenoneoxime 

Downstream Products

• 136741-67-8 6-hydroxy-3-phenyl-1,2-benzisoxazole 
• 6965-78-2 2-benzyl-5-methoxyphenol 
• 1394900-09-4 benzyl (2-hydroxy-4-methoxyphenyl)phenylmethylcarbamate 
• 107804-69-3 7-acetoxymethyl-5-bromo-7,8-dihydro-3-phenylfuro<2,3-g>-1,2-benzisoxazole 
• 107804-50-2 5-bromo-7,8-dihydro-3-phenylfuro<2,3-g>-1,2-benzisoxazole-7-carboxylic acid 
• 107804-49-9 5-bromo-7,8-dihydro-3-phenylfuro<2,3-g>-1,2-benzisoxazole-7-methanol 
• 107804-46-6 3-Phenyl-7,8-dihydro-furo[3',2':3,4]benzo[1,2-d]isoxazole-7-carboxylic acid 
• 107804-45-5 7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-methanol 
• 136741-77-0 6-Allyloxy-3-phenyl-benzo[d]isoxazole 
• 107804-68-2 7-Allyl-3-phenyl-benzo[d]isoxazol-6-ol 

Relevant articles and documents

A divergent and selective synthesis of isomeric benzoxazoles from a single N-Cl imine

A divergent and regioselective synthesis of either 3-substituted benzisoxazoles or 2-substituted benzoxazoles from readily accessible ortho-hydroxyaryl N-H ketimines is described. The reaction proceeds in two distinct pathways through a common N-Cl imine intermediate: (a) N-O bond formation to form benzisoxazole under anhydrous conditions and (b) NaOCl mediated Beckmann-type rearrangement to form benzoxazole, respectively. The reaction path also depends on the electronic nature of the aromatic ring, with the electron-rich aromatic rings favoring the rearrangement and the electron-deficient rings favoring the N-O bond formation. A Beckmann-type rearrangement mechanism via net [1,2]-aryl migration for the formation of 2-substituted benzoxazole is proposed.