136757-04-5

Basic information

• Product Name: 3-AMINO-3-(2-FLUOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER
• Synonyms: 3-AMINO-3-(2-FLUOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER
• CAS NO: 136757-04-5
• Molecular Formula: C11H12FNO2
• Molecular Weight: 209.219
• Mol File: 136757-04-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-AMINO-3-(2-FLUOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(2-FLUOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(136757-04-5)
• EPA Substance Registry System: 3-AMINO-3-(2-FLUOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(136757-04-5)

Safety Data

• Hazardous Substances Data: 136757-04-5(Hazardous Substances Data)

Upstream product

• 1479-24-9 ethyl 2-fluorobenzoylacetate 
• 394-47-8 2-fluorobenzonitrile 
• 105-36-2 ethyl bromoacetate 

Relevant articles and documents

Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters

A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of new C-S, C-N, and N-S bonds. The strategy provides high selectivity for the synthesis of thiazoles/isothiazoles, which have vital applications in drug discovery and development.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

A rapid access to substituted oxazoles via PIFA-mediated oxidative cyclization of enamides

A facile and rapid access to multi-substituted oxazoles has been achieved under mild reaction conditions in a short reaction time. Reaction of enamides 1 with [bis(trifluoroacetoxy)iodo]benzene (PIFA) in trifluoroethanol (TFE) at room temperature for 15?min afforded the desired oxazoles 2 in moderate to excellent yields (58–98%). A wide range of functional group tolerance has been observed for these transformations.