136825-69-9Relevant articles and documents
Bioreversible Protection for the Phospho Group: Chemical Stability and Bioactivation of Di(4-acetoxybenzyl) Methylphosphonate with Carboxyesterase
Freeman, Sally,Irwin, William J.,Mitchell, Antony G.,Nicholls, Dave,Thomson, William
, p. 875 - 877 (1991)
In contrast to high chemical stability (t1/2 55.4 h at 36.4 deg C), with porcine liver carboxyesterase the title compound 1 spontaneously decomposes first to the monoester 2 then to methylphosphonate, both reactions proceeding via the 4-hydroxybenzyl intermediates 3 and 4.