1369217-04-8Relevant articles and documents
Catalytic enantioselective synthesis of the dopamine D1 antagonist ecopipam
Hajra, Saumen,Bar, Sukanta
, p. 151 - 156 (2012/06/16)
A concise asymmetric synthesis of the potent dopamine D1 antagonist, ecopipam, has been accomplished in six steps with 33% overall yield via catalytic enantioselective aziridination and subsequent one-pot Friedel-Crafts cyclization of an in situ generated tethered aziridine with high diastereo- and enantioselectivities.