1369423-51-7

Basic information

• Product Name: 2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid hydrochloride
• CAS NO: 1369423-51-7
• Molecular Weight: 247.678
• Mol File: 1369423-51-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid hydrochloride(1369423-51-7)
• EPA Substance Registry System: 2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid hydrochloride(1369423-51-7)

Safety Data

• Hazardous Substances Data: 1369423-51-7(Hazardous Substances Data)

Usage

General Description

The chemical 2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid hydrochloride is a compound with a molecular formula of C10H13NO4·HCl. It is a derivative of the amino acid tyrosine and is often used as a precursor in the synthesis of various pharmaceuticals. 2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid hydrochloride is known for its antioxidant properties and has been studied for its potential in treating oxidative stress-related diseases. Additionally, it has been investigated for its role in the synthesis of dopamine and other neurotransmitters in the brain. Its hydrochloride form makes it more soluble in water, allowing for easier administration and formulation in medicinal applications.

Upstream product

• 1395919-79-5 (S)-3-(1-naphthoyl)-4-(benzo[d][1,3]dioxol-5-ylmethyl)-2,2,4-trimethyloxazolidin-5-one 
• 1395919-80-8 (S)-2-(1-naphthamido)-3-(benzo[d][1,3]dioxol-5-yl)-2-methylpropanoic acid 
• 1369423-38-0 (R)-4-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-2-phenyloxazol-5(4H)-one 

Downstream Products

• 62365-02-0 2-acetamidoethyl S-3-(3,4-dihydroxyphenyl)-2-methylalaninate 

Relevant articles and documents

Memory of chirality of tertiary aromatic amide: Application to the asymmetric synthesis of (S)-α-methylDOPA

We describe an original asymmetric synthesis of (S)-α-methylDOPA proceeding by the concept of memory of chirality, the only source of chirality being the starting d-alanine. The initial chirality of the amino acid is temporarily transferred to a dynamic axial chirality of a tertiary aromatic amide. The (S)-α-methylDOPA hydrochloride is obtained after four steps with 98% ee.

(S)-ALPHA-FLUOROMETHYLTYROSINE AS DECARBOXYLASE INHIBITORS FOR USE IN THE TREATMENT OF HYPOTENSION

Provided are methods of using and drug delivery systems comprising inhibitors of pathogenic, bacterial metabolite production and conjugates of the inhibitors.

Palladium-catalyzed asymmetric benzylation of azlactones

Asymmetric benzylation of prochiral azlactone nucleophiles enables the catalytic introduction of a benzyl group towards the synthesis of α,α-disubstituted amino acids. Herein, we report an enantioselective palladium-catalyzed process using chiral bis(diphenylphosphinobenzoyl)diamine (dppba) ligands. Naphthalene- and heterocycle-based methyl carbonates react with a number of azlactones derived from both natural and unnatural amino acids. Monocyclic benzylic electrophiles, for which the barrier to ionization is higher, must employ a phosphate leaving group in order to react. Reaction conditions for electron-rich and -neutral benzylic electrophiles have been developed, and the scope of the reaction has been explored with respect to both reaction partners. The high levels of asymmetric induction, as well as the reactivity pattern of the electrophiles, suggest an η3-benzyl intermediate that arises through two distinct pathways. Attack on benzyl: Palladium-catalyzed asymmetric benzylation methodology is demonstrated on prochiral azlactone nucleophiles. The use of naphthyl, heterocyclic, and monocyclic benzylic electrophiles demonstrates the wide reaction scope (see scheme; Cp=cyclopentadienyl). The benzylation products are readily converted into enantioenriched α,α-disubstituted amino acids.