1369534-94-0

Basic information

• Product Name: 2-(4-bromophenoxy)-1,3-diacetoxypropane
• Synonyms: 2-(4-bromophenoxy)-1,3-diacetoxypropane
• CAS NO: 1369534-94-0
• Molecular Weight: 331.163
• Mol File: 1369534-94-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenoxy)-1,3-diacetoxypropane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenoxy)-1,3-diacetoxypropane(1369534-94-0)
• EPA Substance Registry System: 2-(4-bromophenoxy)-1,3-diacetoxypropane(1369534-94-0)

Safety Data

• Hazardous Substances Data: 1369534-94-0(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 105-70-4 2-hydroxypropane-1,3-diyl diacetate 

Downstream Products

• 1228117-35-8 2-(4-bromophenoxy)-1,3-dihydroxypropane 
• 1002129-40-9 C₂₁H₁₇F₃O₄ 
• 1369534-95-1 2-(4-bromophenoxy)-3-tosyloxy-1-propanol 
• 1369534-96-2 3-(4-bromophenoxy)oxetane 
• 1369534-98-4 ethyl (2E,4Z)-5-[4-(oxetan-3-yloxy)phenyl]-5-(4-trifluoromethylphenyl)-2,4-pentadienoate 
• 1002126-70-6 (2E,4Z)-N-(3-hydroxy-2-oxo-1,2,3,4-tetrahydro-5-quinolyl)-5-[4-(oxetan-3-yloxy)phenyl]-5-(4-trifluoromethylphenyl)-2,4-pentadienamide 

Relevant articles and documents

Discovery of novel 5,5-diarylpentadienamides as orally available transient receptor potential vanilloid 1 (TRPV1) antagonists

We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing issues related to pharmacokinetics. Our data suggest that substitution with alkoxy groups on the phenyl ring at the 5-position increases their ability to penetrate the blood-brain barrier. This investigation culminated in the discovery of compound (R)-36b, which showed a good pharmacokinetic profile. In vivo, compound (R)-36b was found to be effective at reversing mechanical allodynia in rats in a dose-dependent manner, and it reversed thermal hyperalgesia in a model of neuropathic pain induced by sciatic nerve injury.