136954-19-3Relevant articles and documents
Alkynylation of Tertiary Cycloalkanols via Radical C-C Bond Cleavage: A Route to Distal Alkynylated Ketones
Wang, Shun,Guo, Li-Na,Wang, Hua,Duan, Xin-Hua
, p. 4798 - 4801 (2015)
An efficient Na2S2O8-promoted radical coupling of tertiary cycloalkanols with alkynyl hypervalent iodide reagents via C-C bond cleavage was developed. This tandem ring-opening/alkynylation procedure showed some advantages,
Domino N2-Extrusion-Cyclization of Alkynylarylketone Derivatives for the Synthesis of Indoloquinolines and Carbocycle-Fused Quinolines
Akkachairin, Bhornrawin,Tummatorn, Jumreang,Khamsuwan, Narumol,Thongsornkleeb, Charnsak,Ruchirawat, Somsak
, p. 11254 - 11268 (2018/09/06)
New synthetic approaches for the synthesis of indoloquinolines and carbocycle-fused quinolines have been developed employing alkynylketone substrates. These synthetic transformations involved the application of N2-extrusion of azido complexes as a key step to generate carbodiimidium ion and nitrilium ion in situ, which further cyclized intramolecularly with alkyne via a domino process to provide indoloquinolines and carbocycle-fused quinolines, respectively, in moderate to good yields.
Formal γ-alkynylation of ketones via Pd-catalyzed C-C cleavage
Ziadi, Asraa,Correa, Arkaitz,Martin, Ruben
supporting information, p. 4286 - 4288 (2013/05/23)
A formal γ-alkynylation of ketones via Pd-catalyzed C-C bond-cleavage is presented. The method allows for the coupling of tert-cyclobutanols and bromoacetylenes, giving access to versatile alkynes that are beyond reach otherwise.
