13696-15-6

Basic information

• Product Name: Benzopyrronium
• Synonyms: Benzopyrronium
• CAS NO: 13696-15-6
• Molecular Formula: Br*C₂₀H₂₄NO₃
• Molecular Weight: 0
• Mol File: 13696-15-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: Benzopyrronium(CAS DataBase Reference)
• NIST Chemistry Reference: Benzopyrronium(13696-15-6)
• EPA Substance Registry System: Benzopyrronium(13696-15-6)

Safety Data

• Hazardous Substances Data: 13696-15-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H24NO3.BrH/c1-21(2)14-13-18(15-21)24-19(22)20(23,16-9-5-3-6-10-16)17-11-7-4-8-12-17;/h3-12,18,23H,13-15H2,1-2H3;1H/q+1;/p-1

Upstream product

• 74-83-9 methyl bromide 
• 3608-68-2 1-methylpyrrolidin-3-yl 2-hydroxy-2,2-diphenylacetate 
• 13220-33-2 1-methyl-3-pyrrolidinol 
• 76-93-7 Benzilic acid 

Relevant articles and documents

Identification of mepenzolate derivatives with long-acting bronchodilatory activity

The standard treatment for chronic obstructive pulmonary disease is a combination of anti-inflammatory drugs and bronchodilators. We recently found that mepenzolate bromide (MP), an antagonist for human muscarinic M3 receptor (hM3R), has both anti-inflammatory and short-acting bronchodilatory activities. To obtain MP derivatives with longer-lasting bronchodilatory activity, we synthesized hybrid compounds based on MP and two other muscarinic antagonists with long-acting bronchodilatory activity glycopyrronium bromide (GC) and aclidinium bromide (AD). Of these three synthesized hybrid compounds (MP-GC, GC-MP, MP-AD) and MP, MP-AD showed the highest affinity for hM3R and had the longest lasting bronchodilatory activity, which was equivalent to that of GC and AD. Both MP-GC and MP-AD exhibited an anti-inflammatory effect equivalent to that of MP, whereas, in line with GC and AD, GC-MP did not show this effect. We also confirmed that administration of MP-AD suppressed elastase-induced pulmonary emphysema in a mouse model. These findings provide important information about the structure-activity relationship of MP for both bronchodilatory and anti-inflammatory activities.