1370010-29-9Relevant articles and documents
Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor
Xu, Heng,Zhang, Haibo,Luan, Linbo,Xu, Yan,Li, Chengyong,Wang, Yonghui,Han, Fangbin,Yang, Ting,Ren, Feng,Xiang, Jia-Ning,Elliott, John D.,Zhao, Yonggang,Guo, Taylor B.,Lu, Hongtao,Zhang, Wei,Hirst, David,Lindon, Matthew,Lin, Xichen
scheme or table, p. 2456 - 2459 (2012/05/05)
High-throughput screening of GSK compound collection led to the discovery of a novel series of thiadiazole amides as potent and S1P3-sparing sphingosine-1-phosphate 1 (S1P1) receptor agonists. Synthesis, structure and activity relationship, selectivity, and some developability properties are described.
