1370251-38-9

Basic information

• Product Name: N-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine
• Synonyms: N-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine
• CAS NO: 1370251-38-9
• Molecular Weight: 417.835
• Mol File: 1370251-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine(1370251-38-9)
• EPA Substance Registry System: N-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine(1370251-38-9)

Safety Data

• Hazardous Substances Data: 1370251-38-9(Hazardous Substances Data)

Upstream product

• 1370251-34-5 5-(5-nitrofuran-2-yl)-N-(prop-2-ynyl)-1,3,4-thiadiazol-2-amine 
• 63777-70-8 2-chlorobenzylazide 
• 4015-11-6 2-chloro-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazole 

Relevant articles and documents

Synthesis and anti-leishmanial activity of 5-(5-nitrofuran-2-yl)-1,3,4- thiadiazol-2-amines containing N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] moieties

A novel series of 5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amines were synthesized by introducing N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] moiety as a new functionality on the C-2 amine of thiadiazole ring via click chemistry. The title compounds namely, N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]-5-(5- nitrofuran-2-yl)-1,3,4-thiadiazol-2-amines (3a-n) were characterized by IR, NMR and MS spectra. These compounds were evaluated for their in vitro anti-leishmanial activity against promostigote form of the Leishmania major. Most compounds exhibited good anti-leishmanial activity against the promastigote form of L. major. The most active compound against promostigotes was found to be 4-methylbenzyl analog 3i, which significantly decreases the number of intracellular amastigotes per macrophage, percentage of macrophage infectivity and infectivity index.