1370251-92-5

Basic information

• Product Name: 8-phenoxyquinazoline-2,4-diamine
• CAS NO: 1370251-92-5
• Molecular Weight: 252.275
• Mol File: 1370251-92-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-phenoxyquinazoline-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-phenoxyquinazoline-2,4-diamine(1370251-92-5)
• EPA Substance Registry System: 8-phenoxyquinazoline-2,4-diamine(1370251-92-5)

Safety Data

• Hazardous Substances Data: 1370251-92-5(Hazardous Substances Data)

Upstream product

• 124-46-9 guanidine hydrogen carbonate 
• 108-95-2 phenol 
• 425379-16-4 2-bromo-3-fluorobenzonitrile 

Relevant articles and documents

Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors

The results of a high-throughput screening assay using the DENV-2 replicon showed that the 2,4-diaminoquinazoline derivative 4a has a high dengue virus inhibitory activity (EC50 = 0.15 μM). A series of 2,4-diaminoquinazoline derivatives based on 4a as a lead compound were synthesized and subjected to structure-antidengue activity relationship studies. Among the series of 2,4-diaminoquinazoline derivative probed, 4o was observed to display both the highest antiviral potency (EC50 = 2.8 nM, SI > 1000) and an excellent pharmacokinetic profile.