1370335-41-3

Basic information

• Product Name: C₂₂H₂₁F₃N₄O₃
• Synonyms: C₂₂H₂₁F₃N₄O₃
• CAS NO: 1370335-41-3
• Molecular Weight: 446.429
• Mol File: 1370335-41-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁F₃N₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁F₃N₄O₃(1370335-41-3)
• EPA Substance Registry System: C₂₂H₂₁F₃N₄O₃(1370335-41-3)

Safety Data

• Hazardous Substances Data: 1370335-41-3(Hazardous Substances Data)

Upstream product

• 146552-66-1 benzyl (2-azidoethyl)carbamate 
• 501-53-1 benzyl chloroformate 
• 134307-72-5 2-(((benzyloxy)carbonyl)amino)ethyl 1-methanesulfonate 
• 77987-49-6 benzyl 2-hydroxyethylcarbamate 
• 641571-13-3 3-(4-methyl-imidazol-1-yl)-5-trifluoromethylbenzoic acid 
• 72080-83-2 2-benzyloxycarbonylaminoethylamine 

Downstream Products

• 1370335-61-7 C₁₄H₁₅F₃N₄O 
• 1261242-36-7 N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide 

Relevant articles and documents

Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies

A series of imidazothiazole derivatives possessing potential activity against melanoma cells were investigated for molecular mechanism of action. The target compounds were tested against V600E-B-RAF and RAF1 kinases. Compound 1zb is the most potent agains

Synthesis of new 6-(4-Fluorophenyl)-5-(2-substituted pyrimidin-4-yl) imidazo[2,1-b] thiazole derivatives and their antiproliferative activity against melanoma cell line

Synthesis of a new series of pyrimidinyl-imidazo[2,1-b]thiazole derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the pyrimidinyl ring side chain was investigated.