1370339-20-0

Basic information

• Product Name: Fmoc-D-Ser(Ac3GlcNAcβ)-OH
• Synonyms: Fmoc-D-Ser(Ac3GlcNAcβ)-OH
• CAS NO: 1370339-20-0
• Molecular Weight: 656.643
• Mol File: 1370339-20-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Fmoc-D-Ser(Ac3GlcNAcβ)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-D-Ser(Ac3GlcNAcβ)-OH(1370339-20-0)
• EPA Substance Registry System: Fmoc-D-Ser(Ac3GlcNAcβ)-OH(1370339-20-0)

Safety Data

• Hazardous Substances Data: 1370339-20-0(Hazardous Substances Data)

Upstream product

• 10378-06-0 (3aR)-6t,7c-diacetoxy-5c-acetoxymethyl-2-methyl-(3ar,7ac)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole 
• 73724-45-5 (R)-N-(fluoren-9-ylmethoxycarbonyl)serine 
• 3006-60-8 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucopyranose 
• 3068-34-6 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl chloride 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 

Relevant articles and documents

A silyl ether-protected building block forO-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection

In this report, we introduce a novel building block for Fmoc/tBu solid phase peptide synthesis (SPPS) of β-linkedO-GlcNAcylated peptides. This building block carries acid labile silyl ether protecting groups, which are fully removed under TFA-mediated peptide cleavage conditions from the resin, thus requiring fewer synthetic steps and no intermediate purification as compared to other acid or base labile protecting group strategies.

O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes

(Chemical Equation Presented) Cytosolic and nuclear proteins may be subject to both O-GlcNAcylation and proteasomal degradation. By means of activity-based profiling, we demonstrate that O-GlcNAc serinecontaining peptide epoxyketones bind to the proteasome catalytic active sites and thus provide the first clear evidence that proteasomes recognize peptides post-translationally modified with a GlcNAc moiety.