137036-54-5

Basic information

• Product Name: (3S)-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
• Synonyms: (3S)-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one;(S)-3-aMino-2,3,4,5-tetrahydro-1H-benzazepin-2-one;2H-1-Benzazepin-2-one, 3-aMino-1,3,4,5-tetrahydro-, (3S)-;(S)-3-amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one;(S)-3-Amino-1,3,4,5-tetrahydro-benzo[b]azepin-2-one
• CAS NO: 137036-54-5
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Product Categories: PHARMACEUTICAL INTERMEDIATES
• Mol File: 137036-54-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 377.524°C at 760 mmHg
• Flash Point: 182.12°C
• Appearance: /
• Density: 1.144g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: (3S)-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(137036-54-5)
• EPA Substance Registry System: (3S)-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(137036-54-5)

Safety Data

• Hazardous Substances Data: 137036-54-5(Hazardous Substances Data)

Usage

General Description

(3S)-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one is a chemical compound that belongs to the class of organic compounds known as tetrahydroisoquinolines. It is a cyclic compound containing a 1-azabicyclo[2.2.2]octane skeleton, which is a core structure for a variety of biologically active compounds. (3S)-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one is a synthetic building block used in the development of pharmaceutical drugs and can also be used as a research reagent in chemical and biological studies. Its unique structure makes it a valuable tool in drug discovery, with potential applications in the treatment of various diseases and disorders.

InChI:InChI=1/C10H12N2O/c11-8-6-5-7-3-1-2-4-9(7)12-10(8)13/h1-4,8H,5-6,11H2,(H,12,13)/t8-/m0/s1

Upstream product

• 86499-35-6 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 156247-61-9 (S)-tert-butyl (2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamate 
• 602307-76-6 (5a-hydroxy-1-methoxy-2-oxo-2,3,4,5,5a,9a-hexahydro-1H-benzo[b]azepin-3-yl)-carbamic acid benzyl ester 
• 216753-94-5 (S)-4-(2-Amino-phenyl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester 
• 97278-68-7 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine 
• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 140700-64-7 3-iodo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 145554-02-5 3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide 
• 1539309-79-9 {(S)-1-[(S)-1-(5-fluoro-2-methoxy-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3yl carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester 
• 958075-62-2 tert-butyl [(3S)-2-oxo-7-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]carbamate 
• 958075-63-3 (3S)-3-amino-7-phenyl-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one hydrochloride 
• 958075-59-7 (2R,3R,4S,5R,6E)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-N-[(3S)-2-oxo-7-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]non-6-enamide 
• 958075-64-4 (2R,3R,4S,5R,6E)-7-cyclopentyl-3,4,5-trihydroxy-2-methoxy-N-[(3S)-2-oxo-7-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]hept-6-enamide 

Relevant articles and documents

HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Disclosed are compounds having the formula (I) wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

Synthesis of optically active α-aminobenzolactam via an oxidative-cyclization reaction

A convergent pathway for the asymmetric synthesis of (-)-α-aminobenzolactam 1 is described. For the first time, the key intermediate N-methoxybenzolactam 8 was prepared from L-homophenylalanine ethyl ester hydrochloride (LHPE·HCl) 5 by employing an oxidat

A novel 3-substituted benzazepinone growth hormone secretagogue (L- 692,429)

The 3-substituted benzazepinone, L-692,429 (compound 1), is the prototype compound of a novel class of compounds that stimulate release of growth hormone (GH). The molecule evolved from efforts to identify a non-peptide mimic of the growth hormone-releasing hexapeptide, GHRP-6. Compound 1 is prepared by sequential attachment of dimethyl-β-alanine and 2'- biphenylyltetrazole side chains to a chiral 3-aminobenzolactam nucleus. Comparison of the biological activity of 1 with the corresponding six- and eight-membered lactam analogs shows the seven-membered benzazepinone skeleton to be preferred. Molecular modeling of the structurally diverse GH secretagogues, L-692,429 and GHRP-6, was performed.