1370371-79-1Relevant articles and documents
A concise synthesis of tetrahydroisoquinoline-1-carboxylic acids using a Petasis reaction and Pomeranz-Fritsch-Bobbitt cyclization sequence
Chrzanowska, Maria,Grajewska, Agnieszka,Meissner, Zofia,Rozwadowska, Maria,Wiatrowska, Iwona
experimental part, p. 3092 - 3097 (2012/06/01)
A sequence of two reactions: the Petasis reaction, in which an aminoacetaldehyde acetal was used as the amine component, followed by Pomeranz-Fritsch-Bobbitt cyclization, has been shown to be a convenient and simple method for the synthesis of tetrahydroisoquinoline-1-carboxylic acids. Using this method several acids have been prepared in good to excellent yields and characterized as hydrochloride salts.