137043-30-2

Basic information

• Product Name: (3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione
• Synonyms: (3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione
• CAS NO: 137043-30-2
• Molecular Weight: 498.533
• Mol File: 137043-30-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione(CAS DataBase Reference)
• NIST Chemistry Reference: (3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione(137043-30-2)
• EPA Substance Registry System: (3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione(137043-30-2)

Safety Data

• Hazardous Substances Data: 137043-30-2(Hazardous Substances Data)

Upstream product

• 137023-14-4 1-Acetoxymethyl-2,4,5-trimethoxy-3-methylbenzene 
• 137023-21-3 2,4-Dimethoxy-3-methyl-5-acetoxymethylphenol 
• 137023-15-5 1-Hydroxymethyl-2,4,5-trimethoxy-3-methylbenzene 
• 3027-05-2 N,N'-diacetylpiperazin-2,5-dione 
• 60059-09-8 2,4,5-trimethoxy-3-methylbenzaldehyde 

Downstream Products

• 113296-80-3 (±)-(Z)-3-(2,4,5-trimethoxy-3-methylbenzyl)-6-(2,4,5-trimethoxy-3-methylbenzylidene)-2,5-piperazinedione 
• 137043-31-3 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6β)-piperazinedione 
• 137043-31-3 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione 

Relevant articles and documents

One-pot α-amidosulfone-mediated variation of the pictet-Spengler tetrahydroisoquinoline synthesis, suitable for amide-type substrates

The development of Pictet-Spengler reactions from amide substrates is a challenging problem. We report here that the reaction between amide-type compounds (including carbamates, amides, ureas and diketopiperazines), aldehydes and p-toluenesulfinic acid constitutes an efficient method for the preparation of tetrahydroisoquinolines or pyrazino-[2,1-b]isoquinolines. Unlike previously known methods, this one-pot Pictet-Spengler protocol avoids the need for strong Lewis or Br?nsted acid catalysts.

Saframycin synthetic studies

A conceptually simple and direct synthetic route to racemic saframycyn B, a bis-isoquinoline quinone antitumor antibiotic, was studied relying on transformations of a key C-2 symmetric intermediate.