1370698-27-3

Basic information

• Product Name: Aminooxy-PEG7-methane
• Synonyms: Aminooxy-PEG7-methane
• CAS NO: 1370698-27-3
• Molecular Formula: C15H33NO8
• Molecular Weight: 355.42442
• Mol File: 1370698-27-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Aminooxy-PEG7-methane(CAS DataBase Reference)
• NIST Chemistry Reference: Aminooxy-PEG7-methane(1370698-27-3)
• EPA Substance Registry System: Aminooxy-PEG7-methane(1370698-27-3)

Safety Data

• Hazardous Substances Data: 1370698-27-3(Hazardous Substances Data)

Usage

Description

Aminooxy-PEG7-methane is an aqueous soluble PEG (polyethylene glycol) linker that features an aminooxy (ONH2) group, which is highly reactive with aldehydes to form an oxime bond. The presence of a reductant can lead to the formation of a hydroxylamine linkage. Due to their high reactivity and sensitivity, aminooxy compounds, including Aminooxy-PEG7-methane, are not suitable for long-term storage and should be used immediately, preferably within one week.

Uses

Used in Pharmaceutical Industry:
Aminooxy-PEG7-methane is used as a reactive PEG linker for the conjugation of drugs or other bioactive molecules to enhance their solubility, stability, and bioavailability. The formation of oxime or hydroxylamine linkages allows for the creation of stable drug conjugates with improved pharmacokinetic properties.
Used in Bioconjugation:
Aminooxy-PEG7-methane is used as a bioconjugation agent to attach biological molecules, such as proteins or peptides, to other molecules, like nanoparticles or drug carriers. The reactive aminooxy group facilitates the formation of stable covalent bonds, enabling the development of novel bioconjugates with tailored properties and functions.
Used in Drug Delivery Systems:
Aminooxy-PEG7-methane is used as a component in the design of drug delivery systems, where it can help in the attachment of therapeutic agents to PEGylated carriers. This enhances the circulation time, reduces immunogenicity, and improves the targeting of drugs to specific cells or tissues, ultimately leading to more effective treatments with fewer side effects.
Used in Chemical Synthesis:
Aminooxy-PEG7-methane is used as an intermediate in the synthesis of various chemical compounds, particularly those involving the formation of oxime or hydroxylamine linkages. Its aqueous solubility and reactivity make it a valuable building block for the development of new molecules with potential applications in various fields, including materials science, pharmaceuticals, and diagnostics.