137104-49-5Relevant articles and documents
New α- and β-cyclodextrin derivatives with cinchona alkaloids used in asymmetric organocatalytic reactions
Tichá, Iveta Chena,Hybelbauerová, Simona,Jind?ich, Jind?ich
, p. 830 - 839 (2019)
The preparation of new organocatalysts for asymmetric syntheses has become a key stage of enantioselective catalysis. In particular, the development of new cyclodextrin (CD)-based organocatalysts allowed to perform enantioselective reactions in water and
Highly Regio- and Enantioselective Alkoxycarbonylative Amination of Terminal Allenes Catalyzed by a Spiroketal-Based Diphosphine/Pd(II) Complex
Liu, Jiawang,Han, Zhaobin,Wang, Xiaoming,Wang, Zheng,Ding, Kuiling
, p. 15346 - 15349 (2015/12/26)
An enantioselective alkoxycarbonylation-amination cascade process of terminal allenes with CO, methanol, and arylamines has been developed. It proceeds under mild conditions (room temperature, ambient pressure CO) via oxidative Pd(II) catalysis using an aromatic spiroketal-based diphosphine (SKP) as a chiral ligand and a Cu(II) salt as an oxidant and affords a wide range of α-methylene-β-arylamino acid esters (36 examples) in good yields with excellent enantioselectivity (up to 96% ee) and high regioselectivity (branched/linear > 92:8). Preliminary mechanistic studies suggested that the reaction is likely to proceed through alkoxycarbonylpalladation of the allene followed by an amination process. The synthetic utility of the protocol is showcased in the asymmetric construction of a cycloheptene-fused chiral β-lactam.
Palladium-catalyzed α-regioselective allylic amination of Morita-Baylis-Hillman acetates with simple aromatic amines
Wang, Yan,Liu, Li,Wang, Dong,Chen, Yong-Jun
, p. 6908 - 6913 (2012/11/07)
An efficient allylic amination of Morita-Baylis-Hillman acetates with simple aromatic amines provided good yields with excellent α- regioselectivity (up to exclusive α-product) under the catalysis of Pd2(dba)3/ferrocene-type diphosph
