137138-52-4

Basic information

• Product Name: ethyl isoeugenol
• Synonyms: ethyl isoeugenol
• CAS NO: 137138-52-4
• Molecular Weight: 192.258
• Mol File: 137138-52-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl isoeugenol(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl isoeugenol(137138-52-4)
• EPA Substance Registry System: ethyl isoeugenol(137138-52-4)

Safety Data

• Hazardous Substances Data: 137138-52-4(Hazardous Substances Data)

Upstream product

• 74368-00-6 4-allyl-1-ethoxy-2-methoxybenzene 
• 74-96-4 ethyl bromide 
• 5932-68-3 (E)-2-methoxy-4-(1-propenyl)phenol 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 97-53-0 4-allylguaiacol 
• 74-88-4 methyl iodide 
• 102-71-6 triethanolamine 
• 111-90-0 ethoxyethoxyethanol 
• 97-54-1 2-methoxy-4-propenylphenol 
• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 3535-30-6 4-ethoxy-3-methoxybenzoic acid 
• 102898-11-3 5-ethoxy-3-(4-ethoxy-3-methoxy-phenyl)-1-ethyl-6-methoxy-2-methyl-indan 
• 195193-01-2 7-Ethoxy-6-methoxy-3-methyl-3,4-dihydro-cyclobuta[a]naphthalene-1,2-dione 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 102898-11-3 (+/-)-5-ethoxy-3c-(4-ethoxy-3-methoxy-phenyl)-1r-ethyl-6-methoxy-2t-methyl-indan 
• 5932-68-3 (E)-2-methoxy-4-(1-propenyl)phenol 
• 63477-41-8 trans-2-ethoxy-5-(1-propenyl)-phenol 

Relevant articles and documents

Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents

Twenty-eight compounds related to dehydrozingerone (1), isoeugenol (3), and 2-hydroxychalcone (4) were synthesized and evaluated in vitro against human tumor cell replication. Except for isoeugenol analogues 27-35, most compounds exhibited moderate or strong cytotoxic activity against KB, KB-VCR (a multidrug-resistant derivative), and A549 cell lines. In particular, chalcone 15 showed significant cytotoxic activity against the A549 cell line with an IC50 value of 0.6 μg/mL. Furthermore, dehydrozingerone analogue 11 and chalcones 16 and 17 showed significant and similar cytotoxic activity against both KB (IC50 values of 2.0, 1.0, and 2.0 μg/mL, respectively) and KB-VCR (IC50 values of 1.9, 1.0, and 2.0 μ/mL, respectively) cells, suggesting that they are not substrates for the P-glycoprotein drug efflux pump.