1372401-26-7

Basic information

• Product Name: C₁₇H₁₄NO₃^(1-)*K⁽¹⁺⁾
• CAS NO: 1372401-26-7
• Molecular Weight: 319.401
• Mol File: 1372401-26-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₄NO₃^(1-)*K⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₄NO₃^(1-)*K⁽¹⁺⁾(1372401-26-7)
• EPA Substance Registry System: C₁₇H₁₄NO₃^(1-)*K⁽¹⁺⁾(1372401-26-7)

Safety Data

• Hazardous Substances Data: 1372401-26-7(Hazardous Substances Data)

Upstream product

• 1333433-41-2 2-(2-methoxy-3-oxoisoindol-1-yl)-1-phenylethanone 
• 1372401-19-8 2-methoxy-3-(2-oxo-2-phenylethylidene)isoindolin-1-one 
• 1914-20-1 N-methoxyphthalimide 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 

Relevant articles and documents

Regioselective condensation of alkylidenephosphoranes to N-methoxy-and N-anilino-1 H isoindole-1,3-(2 H)-diones

Treatment of 2-methoxyisoindoline-1,3-dione with resonance-stabilized alkylidenephosphoranes afforded the corresponding monoalkenes as the sole reaction product, in ～58-63% yields, whereas more than 80% yields of the same monoolefin products were obtained when the reactions were carried out under microwave conditions. Similarly, 2-(phenylamino)isoindoline-1,3-dione reacted under either thermal or microwave conditions to give only the corresponding monoalkene derivatives. The alkene products from both substrates were further reduced to the corresponding isoindoles using Zn-dust in EtOH. Prediction of the designed compounds and the in vivo anti-inflammation activity of the products in the rat adjuvant model were also studied. The work is the first demonstration of the anti-inflammatory activity of phthalimide derivatives.